Hydrazine → 4,5-Diphenyl-1,2-dihydropyrazol-3-one

HRID 1838626

反応式

HRID 1838626 の反応式
C([O:3][C:4](=O)[CH:5]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:6](=O)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.C(O)(=O)C1(CCC(C(O)=O)C1(C)C)C.[NH2:35][NH2:36]>C(O)C>[C:14]1([C:5]2[C:4](=[O:3])[NH:35][NH:36][C:6]=2[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

5

反応物 3

HCID 9321HydrazineHCID 214911,2,2-Trimethyl-1,3-cyclopentanedicarboxylic acidHCID 11010997Ethyl beta-oxo-alpha-phenylbenzenepropanoate

生成物 1

HCID 2560164,5-Diphenyl-1,2-dihydropyrazol-3-one収率 32.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To 20 mL of an ethanol solution of 1.2 g (4.47mmol) of 3-oxo-2,3-diphenylpropionic acid ethyl ester was added 1.04 g (4.47 mmol) of camphoric acid and 140 μL(4.47 mmol) of hydrazine. After the mixture was refluxed for 20 min, the solvent was removed in vacuo, and the residue was triturated with 40% ethyl acetate/hexane (2 mL) three times to afford 343 mg of 4,5-diphenyl-1,2-dihydropyrazol-3-one in 27% yield.

後処理

  1. temperatureAfter the mixture was refluxed for 20 min
  2. customthe solvent was removed in vacuo
  3. customthe residue was triturated with 40% ethyl acetate/hexane (2 mL) three times

出典と根拠

ORDレコード
ord-a7b335d6ba3d4ef285211df8f3ab7ccf
出典データセット
uspto-grants-2004_01
特許番号
US06673923B2

関連ノート

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