関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-(Trifluoromethyl)aniline | HCID 7375 | — |
| 反応物 | Diethyl (ethoxymethyl)malonate | HCID 98702 | — |
| 生成物 | Diethyl ((alpha,alpha,alpha-trifluoro-m-toluidino)methylene)malonate | HCID 96560 | — |
反応手順
Under a nitrogen atmosphere, a mixture of 3-(trifluoromethyl)aniline (40 mL, 0.32 mmol) and diethyl ethoxymethylmalonate was heated at 100° C. for 3 hours. The reaction mixture was allowed to cool to room temperature at which time the solution solidified to provide 102 g of diethyl 2-{[3-(trifluoromethyl)anilino]methylene}malonate as a cream colored solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06677334B2 |
|---|
| 出典データセット | uspto-grants-2004_01 |
|---|
| ORD ID | ord-d172625ec70c4f7599e49473b2b76871 |
|---|
| 出典メモ | uspto-grants-2004_01 |
|---|
