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Diisopropylethylamine → (2S)-2-[isobutyl(p-tolylsulfonyl)amino]-6-[[2-(4-pyridylamino)acetyl]amino]hexanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | N-phenylpyridin-4-amine | HCID 89945 | — |
| 反応物 | Nalpha-isobutyl-Nalpha-(4-methylbenzenesulfonyl)-Nepsilon-iodoacetyl-L-lysine | HCID 86589941 | — |
| 生成物 | (2S)-2-[isobutyl(p-tolylsulfonyl)amino]-6-[[2-(4-pyridylamino)acetyl]amino]hexanoic acid | HCID 508634 | — |
反応手順
The title compound was prepared from Nα-isobutyl-Nα-(4-methylbenzenesulfonyl)-Nε-iodoacetyl-L-lysine (150 mg, 0.29 mmol, example 105, step B) by following the indications of general procedure H using DIEA (0.10 mL, 0.57 mmol) and 4-amiinopyridine (76 mg, 0.59 mmol). The crude material was purified by preparative HPLC. The product was isolated as a solid (39 mg, 28% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06677367B2 |
| 出典データセット | uspto-grants-2004_01 |
| ORD ID | ord-27937b180fb44074bfb5c771cc8953ad |
| 出典メモ | uspto-grants-2004_01 |