Benzyl Bromide → 3-Phenyl-5-(3-phenylpropyl)isoxazole-4-carboxylic acid

HRID 1840304

反応式

HRID 1840304 の反応式
[C:1]1([C:7]2[C:11]([C:12]([OH:14])=[O:13])=[C:10]([CH2:15][CH2:16]C3C=CC=CC=3)[O:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:23](Br)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[C:1]1([C:7]2[C:11]([C:12]([OH:14])=[O:13])=[C:10]([CH2:15][CH2:16][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[O:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

3

反応物 2

HCID 7498Benzyl BromideHCID 234479063-Phenyl-5-(2-phenylethyl)isoxazole-4-carboxylic acid

生成物 1

HCID 234478873-Phenyl-5-(3-phenylpropyl)isoxazole-4-carboxylic acid収率 72%

実験手順

The title compound was prepared as described for Compound 28A but substituting 2-phenylethylbromide for benzyl bromide. The crude was purified by flash chromatography (ethyl acetate-petroleum ether-acetic acid 1:1:0.01 mL) to afford the title compound (72%).

後処理

  1. customThe title compound was prepared
  2. customThe crude was purified by flash chromatography (ethyl acetate-petroleum ether-acetic acid 1:1:0.01 mL)

出典と根拠

ORDレコード
ord-168ab362c36b44b29c13146257c680bf
出典データセット
uspto-grants-2004_01
特許番号
US06680319B2

関連ノート

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