Triethylamine → HCID 86587417、化合物

反応式

[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[S:12](Cl)(=[O:14])=[O:13].Cl.[O:17]1[CH2:21][CH2:20][CH2:19][NH:18]1.C([N:24](CC)CC)C>>[O:17]1[CH2:21][CH2:20][CH2:19][N:18]1[C:6]1[CH:5]=[C:4]([Cl:11])[C:3]([S:12]([NH2:24])(=[O:14])=[O:13])=[C:2]([Cl:1])[C:7]=1[N+:8]([O-:10])=[O:9]

参加物

反応物 3

HCID 8471Triethylamine

HCID 12304500Isoxazolidine hydrochloride

HCID 234477722,6-Dichloro-3-nitrobenzene-1-sulfonyl chloride

生成物 1

HCID 86587417HCID 86587417、化合物収率 71%

実験手順

Following the general procedure for sulfonamide formation outlined in example 1, 2,6-dichloro-3-nitrobenzenesulfonyl chloride (1.5 g, 5.2 mmol), isoxazolidine hydrochloride (0.56 g, 5.2 mmol) and triethylamine (2.2 mL, 15.5 mmol) were reacted to form the desired product (1.2 g, 71%). EI-MS m/z 327 (M+).