Triethylamine → 3-Chloro-2-fluorophenylisothiocyanate

HRID 1840356ノート

反応式

HRID 1840356 の反応式
[F:1][C:2]1[C:8]([Cl:9])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[C:10](Cl)(Cl)=[S:11].C(N(CC)CC)C.C(OCC)(=O)C>C1(C)C=CC=CC=1.O>[F:1][C:2]1[C:8]([Cl:9])=[CH:7][CH:6]=[CH:5][C:3]=1[N:4]=[C:10]=[S:11]

参加物

7

反応物 4

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 10040ThiophosgeneHCID 750143-Chloro-2-fluoroaniline

生成物 1

HCID 27575833-Chloro-2-fluorophenylisothiocyanate収率 74%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1140Toluene溶媒

実験手順

Into a solution of 2-fluoro-3-chloroaniline (1.0 g, 6.87 mmol) in 30 mL of toluene at room temperature, thiophosgene (0.8 mL, 10.3 mmol) and triethylamine (1.12 mL, 8.24 mmol) were added. The mixture was stirred at room temperature for 16 hours. The mixture was parationed between ethyl acetate and water. The combined organic layer was then concentrated to give the desired product (950 mg, 74%). 1H NMR (CDCl3) δ 7.09 (m, 2H), 7.30 (m, 1H).

後処理

  1. concentrationThe combined organic layer was then concentrated

出典と根拠

ORDレコード
ord-68cb9c62588f4f9db7166c3fd3d9f919
出典データセット
uspto-grants-2004_01
特許番号
US06680317B2

反応ノート

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