Triethylamine → 3-fluoro-2-methylphenylisothiocyanate
反応式
[CH3:1][C:2]1[C:8]([F:9])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[C:10](Cl)(Cl)=[S:11].C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH3:1][C:2]1[C:8]([F:9])=[CH:7][CH:6]=[CH:5][C:3]=1[N:4]=[C:10]=[S:11]参加物
5
実験手順
Into a solution of 2-methyl-3-fluoroaniline (1.0 g, 8.0 mmol) in 30 mL of toluene at room temperature, thiophosgene (0.94 mL, 12 mmol) and triethylamine (1.34 mL, 12 mmol) was added. The mixture was stirred at room temperature for 16 hours. The mixture was partitioned between ethyl acetate and water. The combined organic layer was then concentrated to give the desired product (1.1 g, 82%). EI-MS m/z 168.2 (M+).
後処理
- customThe mixture was partitioned between ethyl acetate and water
- concentrationThe combined organic layer was then concentrated
出典と根拠
- ORDレコード
- ord-29631824a64d4a1494f487d135d9e8d5
- 出典データセット
- uspto-grants-2004_01
- 特許番号
- US06680317B2
反応ノート
読み込み中…