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HRID 1840479作成日：2026年10月27日
Piperidine → 3-(3-methyl-1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide
https://huagongshe.com/reaction/1840479
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 3-Methyl-1H-indole-2-carbaldehyde | HCID 277260 | — |
| 反応物 | N-methyl-2-oxoindoline-5-sulfonamide | HCID 10176909 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(3-methyl-1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide | HCID 54565082 | 70% |
反応手順
A mixture of 5-methylaminosulfonyl-2-oxindole (90 mg), 3-methylindole-2-carbaldehyde (56 mg) (prepared according to Synthetic Communications, 1986, 16, 1799) and piperidine (30 mg) in ethanol (1 mL) was heated in a sealed tube at 90° C. for overnight. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in oven for overnight to give 90 mg (70% yield) of 3-(3-methyl-1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide (mixture of isomers).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06680335B2 |
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| 出典データセット | uspto-grants-2004_01 |
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| ORD ID | ord-9dcaf09da6084b1dacc6d3ce33d6b17d |
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| 出典メモ | uspto-grants-2004_01 |
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