関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | Indole-2-carboxaldehyde | HCID 96389 | — |
| 反応物 | 2-Oxoindoline-5-sulfonamide | HCID 10198232 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide | HCID 54232128 | 83% |
反応手順
A mixture of 5-aminosulfonyl-2-oxindole (106 mg) (prepared as described in Compound IN-02), indole-2-carbaldehyde (87 mg) (prepared according to Synthetic Communications, 1993, 23, 3109) and piperidine (4 mg) in ethanol (2 mL) was heated in a sealed tube at 90° C. for 3 hours. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in oven for overnight to give 140 mg (83% yield) of 3-(1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide as an orange solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06680335B2 |
|---|
| 出典データセット | uspto-grants-2004_01 |
|---|
| ORD ID | ord-6e454b9f1c7848cc8c88aa3574f4c59a |
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| 出典メモ | uspto-grants-2004_01 |
|---|
