Piperidine → 3-(1H-indol-2-ylmethylene)-4-methyl-1,3-dihydroindol-2-one

HRID 1840498ノート

反応式

HRID 1840498 の反応式
[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][C:5](=[O:11])[NH:6]2.[NH:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[C:13]1[CH:21]=O.N1CCCCC1>C(O)C>[NH:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[C:13]1[CH:21]=[C:4]1[C:3]2[C:7](=[CH:8][CH:9]=[CH:10][C:2]=2[CH3:1])[NH:6][C:5]1=[O:11]

参加物

5

反応物 3

HCID 8082PiperidineHCID 96389Indole-2-carboxaldehydeHCID 125793824-Methyl-1,3-dihydro-2H-indol-2-one

生成物 1

HCID 542071973-(1H-indol-2-ylmethylene)-4-methyl-1,3-dihydroindol-2-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
95 °C

実験手順

A mixture of 4-methyl-2-oxindole (147 mg), indole-2-carbaldehyde (174 mg) (prepared according to Synthetic Communications, 1993, 23, 3109) and piperidine (10 mg) in ethanol was heated in a sealed tube at 95° C. for 4 hours. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in vacuum oven for overnight to give 3-(1H-indol-2-ylmethylene)-4-methyl-1,3-dihydro-indol-2-one.

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationThe solid was collected by vacuum filtration
  3. washwashed with cold ethanol
  4. customdried in vacuum oven for overnight

出典と根拠

ORDレコード
ord-cdb528b386884eb7b0ee51c1ea765940
出典データセット
uspto-grants-2004_01
特許番号
US06680335B2

反応ノート

読み込み中…