Hydrochloric Acid → 4-(7-chloro-2H-benzopyran-3-sulfonyl)-1-(piperidin-4-ylmethyl)-2-piperazinone hydrochloride

HRID 1840567ノート

反応式

HRID 1840567 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]2[CH2:20][CH2:19][N:18]([S:21]([C:24]3[CH2:25][O:26][C:27]4[CH:33]=[C:32]([Cl:34])[CH:31]=[CH:30][C:28]=4[CH:29]=3)(=[O:23])=[O:22])[CH2:17][C:16]2=[O:35])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>C(OCC)(=O)C.CO>[ClH:34].[Cl:34][C:32]1[CH:31]=[CH:30][C:28]2[CH:29]=[C:24]([S:21]([N:18]3[CH2:19][CH2:20][N:15]([CH2:14][CH:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)[C:16](=[O:35])[CH2:17]3)(=[O:22])=[O:23])[CH2:25][O:26][C:27]=2[CH:33]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 234473471-[1-(tert-butoxycarbonyl)piperidin-4-ylmethyl]-4-(7-chloro-2H-benzopyran-3-sulfonyl)-2-piperazinone

生成物 1

HCID 234473484-(7-chloro-2H-benzopyran-3-sulfonyl)-1-(piperidin-4-ylmethyl)-2-piperazinone hydrochloride収率 198.4%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To 1-[1-(tert-butoxycarbonyl)piperidin-4-ylmethyl]-4-(7-chloro-2H-benzopyran-3-sulfonyl)-2-piperazinone (1.856 g) were added 4N hydrochloric acid in ethyl acetate (40 ml) and methanol (25 ml), and the mixture was stirred at room temperature for 30 minutes. The reaction solution was concentrated to give colorless crystals of 4-(7-chloro-2H-benzopyran-3-sulfonyl)-1-(piperidin-4-ylmethyl)-2-piperazinone hydrochloride (1.618 g).

後処理

  1. concentrationThe reaction solution was concentrated

出典と根拠

ORDレコード
ord-ebfb5f75a5ba412b8c6f6705c04fc5f6
出典データセット
uspto-grants-2004_01
特許番号
US06680312B2

反応ノート

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