Hydrochloric Acid → 4-(5-Chlorobenzofuran-2-sulfonyl)-1-(piperidin-4-ylmethyl)-2-piperazinone hydrochloride

HRID 1840572ノート

反応式

HRID 1840572 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]2[CH2:20][CH2:19][N:18]([S:21]([C:24]3[O:25][C:26]4[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:27]=4[CH:28]=3)(=[O:23])=[O:22])[CH2:17][C:16]2=[O:34])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>C(OCC)(=O)C.CO>[ClH:33].[Cl:33][C:30]1[CH:31]=[CH:32][C:26]2[O:25][C:24]([S:21]([N:18]3[CH2:19][CH2:20][N:15]([CH2:14][CH:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)[C:16](=[O:34])[CH2:17]3)(=[O:23])=[O:22])=[CH:28][C:27]=2[CH:29]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 234474431-[1-(Tert-butoxycarbonyl)piperidin-4-ylmethyl]-4-(5-chlorobenzofuran-2-sulfonyl)-2-piperazinone

生成物 1

HCID 234473124-(5-Chlorobenzofuran-2-sulfonyl)-1-(piperidin-4-ylmethyl)-2-piperazinone hydrochloride収率 193.7%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To 1-[1-(tert-butoxycarbonyl)piperidin-4-ylmethyl]-4-(5-chlorobenzofuran-2-sulfonyl)-2-piperazinone (270 mg) were added 4N hydrochloric acid in ethyl acetate (8 ml) and methanol (2 ml), and the mixture was stirred at room temperature for 30 minutes. The reaction solution was concentrated to give 4-(5-chlorobenzofuran-2-sulfonyl)-1-(piperidin-4-ylmethyl)-2-piperazinone hydrochloride (229 mg).

後処理

  1. concentrationThe reaction solution was concentrated

出典と根拠

ORDレコード
ord-0c95523da64a41bdac7d44450ca9f6ca
出典データセット
uspto-grants-2004_01
特許番号
US06680312B2

反応ノート

読み込み中…