2-Propenoic acid, 3-(3-chlorophenyl)- → (R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)[E-3-(3-chlorophenyl)propenamide]
反応式
Cl.Cl.[N:3]12[CH2:10][CH2:9][CH:6]([CH2:7][CH2:8]1)[C@@H:5]([NH2:11])[CH2:4]2.[Cl:12][C:13]1[CH:14]=[C:15](/[CH:19]=[CH:20]/[C:21](O)=[O:22])[CH:16]=[CH:17][CH:18]=1>>[N:3]12[CH2:10][CH2:9][CH:6]([CH2:7][CH2:8]1)[C@@H:5]([NH:11][C:21](=[O:22])/[CH:20]=[CH:19]/[C:15]1[CH:16]=[CH:17][CH:18]=[C:13]([Cl:12])[CH:14]=1)[CH2:4]2参加物
3
実験手順
Prepared as a free base by a method analogous to that described in Example 1 from (R)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride and E-3-(3-chlorophenyl)propenoic acid; the compound was purified by chromatography on silica gel using amrnmoniated methanol/chloroform mixtures as the eluent; MS (ES+) 291, 293 (MH+).
後処理
- customPrepared as a free base by a method analogous to
- customthe compound was purified by chromatography on silica gel using amrnmoniated methanol/chloroform mixtures as the eluent