(2E)-3-(4-bromophenyl)prop-2-enoic acid → (R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)[E-3-(4-bromophenyl)propenamide]

HRID 1840905

反応式

HRID 1840905 の反応式
Cl.Cl.[N:3]12[CH2:10][CH2:9][CH:6]([CH2:7][CH2:8]1)[C@@H:5]([NH2:11])[CH2:4]2.[Br:12][C:13]1[CH:18]=[CH:17][C:16](/[CH:19]=[CH:20]/[C:21](O)=[O:22])=[CH:15][CH:14]=1>>[N:3]12[CH2:10][CH2:9][CH:6]([CH2:7][CH2:8]1)[C@@H:5]([NH:11][C:21](=[O:22])/[CH:20]=[CH:19]/[C:16]1[CH:17]=[CH:18][C:13]([Br:12])=[CH:14][CH:15]=1)[CH2:4]2

参加物

3

反応物 2

HCID 737158(2E)-3-(4-bromophenyl)prop-2-enoic acidHCID 12494972(R)-(+)-3-Aminoquinuclidine Dihydrochloride

生成物 1

HCID 20613761(R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)[E-3-(4-bromophenyl)propenamide]

実験手順

Prepared as a free base by a method analogous to that described in Example 1 from (R)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride and E-3-(4-bromophenyl)propenoic acid; the compound was purified by chromatography on silica gel using ammoniated methanol/chloroform mixtures as the eluent; MS (ES+) 335, 337 (MH+H).

後処理

  1. customPrepared as a free base by a method analogous to
  2. customthe compound was purified by chromatography on silica gel using ammoniated methanol/chloroform mixtures as the eluent

出典と根拠

ORDレコード
ord-b2cd7f23c02e49ec9dc24d12864a597d
出典データセット
uspto-grants-2004_01
特許番号
US06683090B1

関連ノート

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