化工社化工社 化学情報印刷レポート · 研究参考用
2-Furanacrylic acid → (S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)[E-3-(2-furyl)propenamide]
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Furanacrylic acid | HCID 643402 | — |
| 反応物 | (3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride | HCID 12494973 | — |
| 生成物 | (S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)[E-3-(2-furyl)propenamide] | HCID 20613779 | — |
反応手順
Prepared as a free base by a method analogous to that described in Example 1 from (S)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride and E-3-(2-furyl)propenoic acid; the compound was purified by chromatography on silica gel using ammoniated methanol/chloroform mixtures as the eluent, followed by recrystallization from ethyl acetate/hexane; MS (ES+) 247 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06683090B1 |
| 出典データセット | uspto-grants-2004_01 |
| ORD ID | ord-5eeea2a48aad4348bbcbd8f09047b1b8 |
| 出典メモ | uspto-grants-2004_01 |