3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) → 3-(3-Chloro-4-fluoro-phenyl)-5-(2-methyl-imidazol-1-yl-methyl)-pyridine Hydrochloride

反応式

Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH2:8][N:9]2[CH:13]=[CH:12][N:11]=[C:10]2[CH3:14])[CH:7]=1.[Cl:15][C:16]1[CH:17]=[C:18](B(O)O)[CH:19]=[CH:20][C:21]=1[F:22]>>[ClH:15].[Cl:15][C:16]1[CH:17]=[C:18]([C:2]2[CH:3]=[N:4][CH:5]=[C:6]([CH2:8][N:9]3[CH:13]=[CH:12][N:11]=[C:10]3[CH3:14])[CH:7]=2)[CH:19]=[CH:20][C:21]=1[F:22]

参加物

反応物 2

HCID 27346603-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride)

HCID 234449653-Bromo-5-(2-methyl-imidazol-1-ylmethyl)-pyridine

生成物 1

HCID 234449973-(3-Chloro-4-fluoro-phenyl)-5-(2-methyl-imidazol-1-yl-methyl)-pyridine Hydrochloride

実験手順

The title compound, MS: m/e=301.1 (M+) was obtained as a yellow solid (53% yield) by the reaction of 3-bromo-5-(2-methyl-imidazol-1-yl-methyl)-pyridine with 3-chloro-4-fluoro-phenyl boronic acid.

出典と根拠

ORDレコード: ord-0d30aa96c5b04dfb8ea4aa8cad63cdc5
出典データセット: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06683097B2

反応ノート

読み込み中…

参加物