2,6-Dichloroaniline → HCID 20614289、化合物

HRID 1841512

反応式

HRID 1841512 の反応式
[N:1]1[C:6]([CH:7]=O)=[CH:5][CH:4]=[CH:3][C:2]=1[CH:9]=O.[Cl:11][C:12]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[C:13]=1[NH2:14]>C1(C)C=CC=CC=1>[Cl:11][C:12]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[C:13]=1[N:14]=[CH:9][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([CH:7]=[N:14][C:13]2[C:12]([Cl:11])=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:19])[N:1]=1

参加物

4

反応物 2

HCID 118462,6-DichloroanilineHCID 794852,6-Diformylpyridine

生成物 1

HCID 20614289HCID 20614289、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

2,6-Pyridinedicarboxaldehyde (1 g, 7.4 mmol) and 2,6-dichloroaniline (2.6 g, 16.0 mmol) were dissolved in 100 ml of toluene. To this solution 4 Å molecular sieves were added. After standing for 2 days, with addition of more 4 Å molecular sieves the mixture was filtered. The solvent was removed in vacuo. The residue was crystallised from ethanol. Yield 1.4 g (45%) of 6. 1H-NMR (CDCl3) δ 8.53 (s, 2H, HC═N), 8.45 (d, 2H, Py-Hm), 8.02 (t, 1H, Py-Hp), 7.36 (d, 4H, ArH), 7.03 (t, 2H, ArH).

後処理

  1. additionTo this solution 4 Å molecular sieves were added
  2. additionAfter standing for 2 days, with addition of more 4 Å molecular sieves the mixture
  3. filtrationwas filtered
  4. customThe solvent was removed in vacuo
  5. customThe residue was crystallised from ethanol

出典と根拠

ORDレコード
ord-c7a8f412815a4161989ab8c8081a657f
出典データセット
uspto-grants-2004_01
特許番号
US06683187B2

関連ノート

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