Potassium Hydroxide → 1-Amino-4,4-difluorocyclohexanecarboxylic acid
反応式
[F:1][C:2]1([F:14])[CH2:13][CH2:12][C:5]2([NH:9]C(=O)N[C:6]2=[O:11])[CH2:4][CH2:3]1.[OH-:15].[K+]>>[NH2:9][C:5]1([C:6]([OH:15])=[O:11])[CH2:12][CH2:13][C:2]([F:14])([F:1])[CH2:3][CH2:4]1参加物
3
実験手順
Under nitrogen gas, 4.10 g of the compound of Example 2A were suspended in 100 ml of 30% strength aqueous potassium hydroxide solution, and the mixture was stirred at reflux overnight. The mixture was concentrated to about 25% of the volume and, at 0-10° C., adjusted to pH 5.5 using concentrated aqueous hydrogen chloride solution. The solution was concentrated and dried. The residue (4.30 g) was used directly for the esterification.
後処理
- temperatureat reflux overnight
- concentrationThe mixture was concentrated to about 25% of the volume and, at 0-10° C.
- concentrationThe solution was concentrated
- customdried
出典と根拠
- ORDレコード
- ord-ec6d698679d6466d9281fbbfd848d459
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08946124B2
反応ノート
読み込み中…