Hydrochloric Acid → Methyl 4-methylpiperidine-4-carboxylate hydrochloride
反応式
C(OC([N:8]1[CH2:13][CH2:12][C:11]([CH3:17])([C:14]([OH:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:18].[CH3:19]O>>[ClH:18].[CH3:19][O:16][C:14]([C:11]1([CH3:17])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[O:15]参加物
4
実験手順
To a stirred solution of 4-methyl-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (1.00 g, 4.10 mmol) in MeOH (2 mL) is added HCl (5 ml, 4 M in dioxane). After 18 h, the mixture is evaporated to dryness, the residue is dissolved in MeOH (3 mL), and the stirred solution is treated with Et2O (45 ml). The resulting solid is filtered and dried to give the title compound.
後処理
- customthe mixture is evaporated to dryness
- dissolutionthe residue is dissolved in MeOH (3 mL)
- additionthe stirred solution is treated with Et2O (45 ml)
- filtrationThe resulting solid is filtered
- customdried
出典と根拠
- ORDレコード
- ord-b6418eab5117486b93060a13a91ce257
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08946203B2
反応ノート
読み込み中…