Hydrochloric Acid → 1-(3,8-Diaza-bicyclo[3.2.1]oct-3-yl)-ethanone hydrochloride
反応式
C(OC([N:8]1[CH:13]2[CH2:14][CH2:15][CH:9]1[CH2:10][N:11]([C:16](=[O:18])[CH3:17])[CH2:12]2)=O)(C)(C)C.[ClH:19].O1CCOCC1>C(Cl)Cl>[ClH:19].[CH:13]12[NH:8][CH:9]([CH2:15][CH2:14]1)[CH2:10][N:11]([C:16](=[O:18])[CH3:17])[CH2:12]2参加物
5
反応条件
- 温度
- 25 °C
実験手順
To a solution of 3-acetyl-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (1.20 g, 4.49 mmol) in DCM (25 mL) is added 4M HCl in 1,4-dioxane (20.0 mL, 80.0 mmol) and the reaction stirred at about 25° C. for 18 hours. The reaction is concentrated, suspended in Et2O, and filtered to afford the title compound (U) as a hydroscopic solid.
後処理
- concentrationThe reaction is concentrated
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-86f155177b3c4d1faf0382b932cf5a35
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08946203B2
反応ノート
読み込み中…