tert-Butyl (1S,4S)-2,5-diazabicyclo[2.2.2]octane-2-carboxylate → (S)-3-{4-[(1S,4S)-1-(2,5-Diaza-bicyclo[2.2.2]oct-2-yl)methyl]-phenyl}-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine

反応式

C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C@@H:21]3[O:30][C:25]4=[N:26][CH:27]=[CH:28][CH:29]=[C:24]4[O:23][CH2:22]3)=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[C:31](OC(N1C[C@@H]2CC[C@H]1CN2)=O)(C)(C)[CH3:32].N1(CC2C=CC([C@@H]3OC4=NC=CC=C4OC3)=CC=2)CCNCC1>>[C@H:10]12[CH2:32][CH2:31][C@H:13]([NH:8][CH2:9]1)[CH2:12][N:11]2[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C@@H:21]2[O:30][C:25]3=[N:26][CH:27]=[CH:28][CH:29]=[C:24]3[O:23][CH2:22]2)=[CH:17][CH:16]=1