Benzhydrylamine → 1-Chloro-3-[(diphenylmethyl)amino]propan-2-ol
反応式
[Cl:1][CH2:2][CH:3]1[CH2:5][O:4]1.[C:6]1([CH:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[NH2:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>CO>[CH:12]([NH:13][CH2:5][CH:3]([OH:4])[CH2:2][Cl:1])([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1参加物
4
実験手順
2-(Chloromethyl)oxirane (92 g, 1 mol) was added dropwise to a solution of diphenyl-methanamine (183 g, 1 mol) in CH3OH (1 L) at 0° C. then the mixture was stirred at r.t. overnight. The mixture was then concentrated in vacuo to give the title compound (201 g, 73%) which was used in next step without further purification.
後処理
- concentrationThe mixture was then concentrated in vacuo
出典と根拠
- ORDレコード
- ord-978cc749e5aa4378afda70fff1e54a04
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08946235B2
反応ノート
読み込み中…