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HRID 1842736作成日：2026年10月26日
p-Toluenesulfonic acid → N-(4-fluoro-2-methoxy-5-nitrophenyl)-5-methyl-4-(1-methylindol-3-yl)pyrimidin-2-amine
https://huagongshe.com/reaction/1842736
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | 4-Fluoro-2-methoxy-5-nitroaniline | HCID 57429072 | — |
| 反応物 | 3-(2-chloro-5-methylpyrimidin-4-yl)-1-methyl-1H-indole | HCID 86677338 | — |
| 溶媒 | 2-Pentanol | HCID 22386 | — |
| 生成物 | N-(4-fluoro-2-methoxy-5-nitrophenyl)-5-methyl-4-(1-methylindol-3-yl)pyrimidin-2-amine | HCID 71239199 | — |
反応手順
A mixture of 3-(2-chloro-5-methylpyrimidin-4-yl)-1-methyl-1H-indole (Intermediate 80, 350 mg, 1.36 mmol), 4-fluoro-2-methoxy-5-nitroaniline (Intermediate 23, 265 mg, 1.43 mmol) and p-toluenesulfonic acid (284 mg, 1.49 mmol) in 2-pentanol (25 mL) was heated at 125° C. for 24 h. The mixture was then cooled and concentrated in vacuo. The resulting gum was used without further purification; m/z: ES+ MH+ 240.13.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08946235B2 |
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| 出典データセット | uspto-grants-2015_02 |
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| ORD ID | ord-c1d648686cb44942b8236cb79171947c |
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| 出典メモ | uspto-grants-2015_02 |
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