ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

1,2-Dichloroethane → N-[[2-(3-Chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-methyl]-2-[4-[[(ethylsulfonyl)amino]-methyl]-3-fluoro-phenyl]-propionamide

HRID 1842988
ノート
印刷プレビュー

反応式

HRID 1842988 の反応式
[CH2:1]([S:3]([NH:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([CH3:18])[C:15]([OH:17])=O)=[CH:10][C:9]=1[F:19])(=[O:5])=[O:4])[CH3:2].[Cl:20][C:21]1[CH:22]=[C:23]([N:27]2[C:31]([CH2:32][NH2:33])=[CH:30][C:29]([C:34]([F:37])([F:36])[F:35])=[N:28]2)[CH:24]=[CH:25][CH:26]=1.C1C=CC2N(O)N=NC=2C=1.C(Cl)CCl>O1CCOCC1>[Cl:20][C:21]1[CH:22]=[C:23]([N:27]2[C:31]([CH2:32][NH:33][C:15](=[O:17])[CH:14]([C:11]3[CH:12]=[CH:13][C:8]([CH2:7][NH:6][S:3]([CH2:1][CH3:2])(=[O:4])=[O:5])=[C:9]([F:19])[CH:10]=3)[CH3:18])=[CH:30][C:29]([C:34]([F:35])([F:36])[F:37])=[N:28]2)[CH:24]=[CH:25][CH:26]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 111,2-DichloroethaneHCID 757711-HydroxybenzotriazoleHCID 66644230(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamineHCID 708165692-(4-(Ethylsulfonamidomethyl)-3-fluorophenyl)propanoic acid

生成物 1

HCID 70816450N-[[2-(3-Chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-methyl]-2-[4-[[(ethylsulfonyl)amino]-methyl]-3-fluoro-phenyl]-propionamide

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

2-(4-(ethyl-sulfonamidomethyl)-3-fluorophenyl)propanoic acid (60 mg, 0.207 mmol) and (1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine (63 mg, 0.228 mmol) were dissolved and mixed in 1,4-dioxane followed by addition of HOBt (42 mg, 0.310 mmol) and EDC (60 mg, 0.313 mmol) and TEA (0.07 mL, 0.518 mmol). The reaction mixture was stirred for overnight and then quenched by water and extracted with EtOAc. Drying (MgSO4) and evaporation of the ethyl acetate followed and the residue was purified by CC (EtOAc/n-hexane) to give the example B17 in pure form (104 mg, 92%).

後処理

  1. customquenched by water
  2. extractionextracted with EtOAc
  3. customDrying
  4. custom(MgSO4) and evaporation of the ethyl acetate
  5. customthe residue was purified by CC (EtOAc/n-hexane)
  6. customto give the example

出典と根拠

ORDレコード
ord-f5165c45d53541fcabadbf8c95729c4f
出典データセット
uspto-grants-2015_02
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08946204B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート