Triethylamine → Lenalidomide

HRID 1843449ノート

反応式

HRID 1843449 の反応式
[CH2:1]1[CH:8]([N:9]2[C:13](=[O:14])[C:12]3[CH:15]=[CH:16][CH:17]=[C:18]([NH2:19])[C:11]=3[CH2:10]2)[C:6](=[O:7])[NH:5][C:3](=[O:4])[CH2:2]1.Cl.C(N(CC)CC)C>CO>[NH2:19][C:18]1[CH:17]=[CH:16][CH:15]=[C:12]2[C:11]=1[CH2:10][N:9]([CH:8]1[CH2:1][CH2:2][C:3](=[O:4])[NH:5][C:6]1=[O:7])[C:13]2=[O:14]

参加物

4

反応物 2

HCID 8471TriethylamineHCID 44234581Lenalidomide hydrochloride

生成物 1

HCID 216326Lenalidomide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
7.5 °C

実験手順

The filtered lenalidomide hydrochloride was resuspended in methanol (500 ml) and triethylamine (1.1 mole equivalent) was slowly added to the reaction mixture. The reaction mixture was cooled to 5-10° C. and the liberated lenalidomide was filtered, washed with methanol and dried.

後処理

  1. filtrationthe liberated lenalidomide was filtered
  2. washwashed with methanol
  3. customdried

出典と根拠

ORDレコード
ord-8f89a87239754c5281a06b3274869598
出典データセット
uspto-grants-2015_02
特許番号
US08946265B2

反応ノート

読み込み中…