Phosphorus oxide (P4O10) → 7-(Trifluoromethyl)-3,4-dihydroisoquinolin-1(2H)-one

HRID 1843864

反応式

HRID 1843864 の反応式
C([O:3][C:4](=O)[NH:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=1)C.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>O=P(Cl)(Cl)Cl>[F:15][C:14]([F:17])([F:16])[C:11]1[CH:12]=[C:13]2[C:8]([CH2:7][CH2:6][NH:5][C:4]2=[O:3])=[CH:9][CH:10]=1

参加物

4

反応物 2

HCID 14812Phosphorus oxide (P4O10)HCID 66801630[2-(4-Trifluoromethyl-phenyl)-ethyl]-carbamic acid ethyl ester

生成物 1

HCID 668015937-(Trifluoromethyl)-3,4-dihydroisoquinolin-1(2H)-one収率 20.24%

試薬・触媒・溶媒 1

HCID 24813Phosphorus oxychloride溶媒

反応条件

温度
105 °C

実験手順

Using the same procedure and workup as described in Example 1, step 4, [2-(4-trifluoromethyl-phenyl)-ethyl]-carbamic acid ethyl ester (I-16b: 2.7 g, 10.340 mmol) in POCl3 (15 mL) was reacted with P2O5 (2.92 g, 20.69 mmol). The resulting mixture was stirred at 105° C. for 2 hours to afford the crude product. Purification by column chromatography on silica gel (2% methanol in DCM) afforded 450 mg of the product (20.24% yield).

後処理

  1. customto afford the crude product
  2. customPurification by column chromatography on silica gel (2% methanol in DCM)

出典と根拠

ORDレコード
ord-89bd677239e44ab5b799c78ce4d615ba
出典データセット
uspto-grants-2015_02
特許番号
US08946260B2

関連ノート

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