化工社化工社 化学情報印刷レポート · 研究参考用
Water → 4-(4-Phenyl-benzoyloxy)-2-hydroxy benzoic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Phenylbenzoyl chloride | HCID 84151 | — |
| 反応物 | 2,4-Dihydroxy benzoic acid tert-butyl ester | HCID 21783547 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(4-Phenyl-benzoyloxy)-2-hydroxy benzoic acid tert-butyl ester | HCID 68585537 | — |
反応手順
A solution of 2,4-dihydroxy benzoic acid tert-butyl ester (420 mg; 2 mmol), triethylamine (202 mg; 2 mmol) and p-phenyl benzoyl chloride (415 mg; 1.9 mmol) in dry CH2Cl2 was stirred under argon atmosphere at room temperature overnight after which time H2O was added. The organic phase was isolated, dried, evaporated to dryness and re-crystallized from 2-propanol to yield 195 mg (25%). MS (LC-MS): 389 (MH−).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07741352B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-10827724f5dc4d76ba023f47ad4fbfa2 |
| 出典メモ | uspto-grants-2010_06 |