Potassium Phosphate, Tribasic → HCID 66807421、化合物

関与物質

反応手順

Using analogous conditions and workup as described for the preparation of Example 1A above, 8-fluoro-3,4-dihydro-2H-benzo[4,5]thieno[3,2-c]pyridin-1-one (I-50g: 100 mg, 0.452 mmol) was reacted with 3-bromo-4-trifluoromethylpyridine (102.26 mg, 0.452 mmol), 1,4-dioxane (3 mL), copper iodide (8.58 mg, 0.0452 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (19.25 mg, 0.135 mmol) and potassium phosphate (286.56 mg, 1.35 mmol) in a vial at 115° C. overnight under nitrogen atmosphere to afford the crude product. Purification by preparative HPLC afforded 15 mg of the product (9.09% yield).

情報源と証拠