Potassium Carbonate → Ethyl 8-[(2,6-difluorobenzyl)oxy]-6-ethynyl-2-methylimidazo[1,2-a]pyridine-3-carboxylate

HRID 1844149ノート

反応式

HRID 1844149 の反応式
[F:1][C:2]1[CH:30]=[CH:29][CH:28]=[C:27]([F:31])[C:3]=1[CH2:4][O:5][C:6]1[C:7]2[N:8]([C:18]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[C:19]([CH3:21])[N:20]=2)[CH:9]=[C:10]([C:12]#[C:13][Si](C)(C)C)[CH:11]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[F:1][C:2]1[CH:30]=[CH:29][CH:28]=[C:27]([F:31])[C:3]=1[CH2:4][O:5][C:6]1[C:7]2[N:8]([C:18]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[C:19]([CH3:21])[N:20]=2)[CH:9]=[C:10]([C:12]#[CH:13])[CH:11]=1

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 86718172Ethyl 8-[(2,6-difluorobenzyl)oxy]-2-methyl-6-[(trimethylsilyl)ethynyl]imidazo[1,2-a]pyridine-3-carboxylate

生成物 1

HCID 86718171Ethyl 8-[(2,6-difluorobenzyl)oxy]-6-ethynyl-2-methylimidazo[1,2-a]pyridine-3-carboxylate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

720 mg ethyl 8-[(2,6-difluorobenzyl)oxy]-2-methyl-6-[(trimethylsilyl)ethynyl]imidazo[1,2-a]-pyridine-3-carboxylate (Example 37A; 1.63 mmol; 1 equivalent) were initially charged in 16 ml of methanol, and 674 mg of potassium carbonate (4.81 mmol, 3 equivalents) were added. The resulting reaction mixture was stirred at room temperature for 2 h. The reaction mixture was then concentrated, water was added and the mixture was extracted three times with ethyl acetate. The combined organic phases were washed with saturated sodium chloride solution and dried over magnesium sulphate, and the filtrate was concentrated. This gave 587.7 mg of crude product (which contained 35% of the methyl ester of the target compound; quantitative yield) which was used without further purification for the next reaction.

後処理

  1. customThe resulting reaction mixture
  2. concentrationThe reaction mixture was then concentrated
  3. additionwater was added
  4. extractionthe mixture was extracted three times with ethyl acetate
  5. washThe combined organic phases were washed with saturated sodium chloride solution
  6. dry with materialdried over magnesium sulphate
  7. concentrationthe filtrate was concentrated
  8. customquantitative yield) which was used without further purification for the next reaction

出典と根拠

ORDレコード
ord-66bdf4b4470e4eea924562e86884ddae
出典データセット
uspto-grants-2015_02
特許番号
US08946215B2

反応ノート

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