Hydrochloric Acid → Methyl 6,6,6-trifluoro-5-hydroxynorleucinate hydrochloride
反応式
[ClH:1].[F:2][C:3]([F:14])([F:13])[CH:4]([OH:12])[CH2:5][CH2:6][C@@H:7]([C:9]([OH:11])=[O:10])[NH2:8].[CH3:15]O>>[ClH:1].[F:2][C:3]([F:13])([F:14])[CH:4]([OH:12])[CH2:5][CH2:6][C@@H:7]([C:9]([O:11][CH3:15])=[O:10])[NH2:8]参加物
4
実験手順
1.4 ml of saturated hydrochloric acid in methanol were added to 150 mg (0.7 mmol) of rac-6,6,6-trifluoro-5-hydroxynorleucine (stereoisomer mixture), and the mixture was stirred under reflux overnight. The reaction solution was concentrated, another 1.5 ml of saturated hydrochloric acid in methanol were added and the mixture was stirred under reflux overnight. The reaction solution was concentrated and the residue was dried under high vacuum. This gave 185 mg (99% of theory) of the target compound.
後処理
- temperatureunder reflux overnight
- concentrationThe reaction solution was concentrated
- additionanother 1.5 ml of saturated hydrochloric acid in methanol were added
- stirringthe mixture was stirred
- temperatureunder reflux overnight
- concentrationThe reaction solution was concentrated
- customthe residue was dried under high vacuum
出典と根拠
- ORDレコード
- ord-fccb93fb15a0462990f4a2d05e95feab
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08946215B2
反応ノート
読み込み中…