化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 4-Amino-o-anisic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | Methyl 4-amino-o-anisate | HCID 168705 | — |
| 溶媒 | Oxolane--water (1/1) | HCID 21881883 | — |
| 生成物 | 4-Amino-o-anisic acid | HCID 75599 | 80% |
反応手順
To a solution of 4-amino-2-methoxy benzoic acid methyl ester (5 g; 27 mmol) in THF/H2O (125 mL/25 mL) was added LiOH (4.8 g; 200 mmol) and the slurry was refluxed for 3.5 hours. The reaction mixture was neutralized using 4 M HCl (aq) and the resulting precipitate isolated by filtration and washed with H2O (2×15 mL) to give 3.26 g (80%) of an off-white solid. Mp. 144-146° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07741352B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-4a58bed4de92424b8104b6c9fd88edfc |
| 出典メモ | uspto-grants-2010_06 |