N,N,2-trimethyl-1-(3-nitro-1H-pyrazol-1-yl)propan-2-amine → 1-[2-(Dimethylamino)-2-methylpropyl]-1H-pyrazol-3-amine

HRID 1844539ノート

反応式

HRID 1844539 の反応式
[CH3:1][N:2]([CH3:15])[C:3]([CH3:14])([CH3:13])[CH2:4][N:5]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[N:6]1>[C].[Pd].C(O)C.C(OCC)(=O)C>[CH3:1][N:2]([CH3:15])[C:3]([CH3:13])([CH3:14])[CH2:4][N:5]1[CH:9]=[CH:8][C:7]([NH2:10])=[N:6]1

参加物

4

反応物 1

HCID 66880823N,N,2-trimethyl-1-(3-nitro-1H-pyrazol-1-yl)propan-2-amine

生成物 1

HCID 583285031-[2-(Dimethylamino)-2-methylpropyl]-1H-pyrazol-3-amine収率 94%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 21584252Ethanol ethylacetate溶媒

実験手順

N,N,2-trimethyl-1-(3-nitro-1H-pyrazol-1-yl)propan-2-amine (70.6 mg) was dissolved in a mixed solution (ethanol-ethyl acetate, 4:1, 5 mL). Then, 10% palladium-carbon (7 mg) was added to the prepared solution, and the solution was subjected to catalytic reduction at 101 kPa for about 2 hours. The reaction mixture was filtrated through Celite, and the filtrate was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (silica gel NH, ethyl acetate:hexane=1:1) to give the title compound as a yellow oil (56.8 mg, yield: 94%).

後処理

  1. filtrationThe reaction mixture was filtrated through Celite
  2. customthe filtrate was evaporated under reduced pressure
  3. customThe obtained residue was purified by silica gel column chromatography (silica gel NH, ethyl acetate:hexane=1:1)

出典と根拠

ORDレコード
ord-7017e47eadb446ed878822deea378193
出典データセット
uspto-grants-2015_02
特許番号
US08946440B2

反応ノート

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