Triethylamine → 5-Tert-butyl-2-methoxy-3-nitro-benzyl methanesulphonate

反応式

[CH3:1][S:2](Cl)(=[O:4])=[O:3].[C:6]([C:10]1[CH:11]=[C:12]([N+:20]([O-:22])=[O:21])[C:13]([O:18][CH3:19])=[C:14]([CH2:16][OH:17])[CH:15]=1)([CH3:9])([CH3:8])[CH3:7].C(N(CC)CC)C>ClCCl>[CH3:1][S:2]([O:17][CH2:16][C:14]1[CH:15]=[C:10]([C:6]([CH3:9])([CH3:7])[CH3:8])[CH:11]=[C:12]([N+:20]([O-:22])=[O:21])[C:13]=1[O:18][CH3:19])(=[O:4])=[O:3]

参加物

実験手順

1.20 ml methanesulphonic acid chloride are added to an ice-cooled solution of 3.43 g (5-tert-butyl-2-methoxy-3-nitro-phenyl)-methanol and 2.40 ml triethylamine in 30 ml dichloromethane. The solution is stirred for 2 h while cooling with ice and then diluted with dichloromethane. The dilute solution is washed three times with water and once with saturated aqueous saline solution, dried (MgSO4) and evaporated to dryness.