2,2-diethoxy-1-(5-(2-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl)-2-thioxo-1,3-dithiol-4-yl)ethanone → 4-(Diethoxymethyl)-4-hydroxy-6,6-dimethyl-4,6-dihydro-[1,3]dithiolo[4,5-c]furan-2-thione

HRID 1844627ノート

反応式

HRID 1844627 の反応式
[CH2:1]([O:3][CH:4]([O:23][CH2:24][CH3:25])[C:5]([C:7]1[S:8][C:9](=[S:22])[S:10][C:11]=1[C:12]([O:15]C1CCCCO1)([CH3:14])[CH3:13])=[O:6])[CH3:2]>C(Cl)Cl>[CH2:1]([O:3][CH:4]([O:23][CH2:24][CH3:25])[C:5]1([OH:6])[O:15][C:12]([CH3:14])([CH3:13])[C:11]2[S:10][C:9](=[S:22])[S:8][C:7]1=2)[CH3:2]

参加物

3

反応物 1

HCID 866713752,2-diethoxy-1-(5-(2-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl)-2-thioxo-1,3-dithiol-4-yl)ethanone

生成物 1

HCID 866713764-(Diethoxymethyl)-4-hydroxy-6,6-dimethyl-4,6-dihydro-[1,3]dithiolo[4,5-c]furan-2-thione

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

10 mg (0.024 mmol) of 2,2-diethoxy-1-(5-(2-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl)-2-thioxo-1,3-dithiol-4-yl)ethanone 5 was dissolved in 5 mL of CH2Cl2 containing 0.1 mL CF3COOH. The reaction mixture was stirred for 12 hours, washed with 20 mL of saturated solution of NaHCO3 and, the organic layer was separated and dried in vacuum to yield the target compound 4 as a solid material. Yield: 7.2 mg (0.02 mmol, 90%).

後処理

  1. washwashed with 20 mL of saturated solution of NaHCO3
  2. customthe organic layer was separated
  3. customdried in vacuum

出典と根拠

ORDレコード
ord-2378754fa236400dba2b3a9649ccd520
出典データセット
uspto-grants-2015_02
特許番号
US08946450B2

反応ノート

読み込み中…