Hydrochloric Acid → N-(piperidin-4-yl)methanesulfonamide hydrochloride

HRID 1844863ノート

反応式

HRID 1844863 の反応式
[CH3:1][S:2]([NH:5][CH:6]1[CH2:11][CH2:10][N:9](C(OCCCC)=O)[CH2:8][CH2:7]1)(=[O:4])=[O:3].[ClH:19]>ClCCl.CO>[ClH:19].[NH:9]1[CH2:8][CH2:7][CH:6]([NH:5][S:2]([CH3:1])(=[O:3])=[O:4])[CH2:11][CH2:10]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 86700931Butyl 4-(methylsulfonamido)piperidine-1-carboxylate

生成物 1

HCID 20569935N-(piperidin-4-yl)methanesulfonamide hydrochloride収率 96.3%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6344Dichloromethane溶媒

実験手順

In a dried reaction flask, butyl 4-(methylsulfonamido)piperidine-1-carboxylate (2.53 g, 9.1 mmol) was dissolved in a mixed solvent of dichloromethane (20 mL) and methanol (5 mL). A dried HCl gas was passed thereto at room temperature for 2 hr, and a white solid was formed. The mixture was filtered and washed with dichloromethane and anhydrous ethyl ether, and dried to obtain a white powdery solid (1.88 g) in a 96.3% yield.

後処理

  1. customa white solid was formed
  2. filtrationThe mixture was filtered
  3. washwashed with dichloromethane and anhydrous ethyl ether
  4. customdried

出典と根拠

ORDレコード
ord-affdfea6bb66441f86ab97dfca59fce5
出典データセット
uspto-grants-2015_02
特許番号
US08946279B2

反応ノート

読み込み中…