Potassium Carbonate → 1-Ethynyl-3-methanesulfonylbenzene
反応式
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([C:11]#[C:12][Si](C)(C)C)[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3].C([O-])([O-])=O.[K+].[K+]>CO>[C:11]([C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([S:2]([CH3:1])(=[O:3])=[O:4])[CH:6]=1)#[CH:12]参加物
4
実験手順
To a solution of 0.24 g (0.95 mmol) of the above (3-methanesulfonyl-phenylethynyl)-trimethyl-silane in methanol (2 mL) was added K2CO3 aq. solution (1 M, 1 mL), the mixture was stirred at room temperature for 1 h. After usual workup, the residue was purified by column chromatography eluted with hexanes/ethyl acetate (v/v=5:1 then 3:1) to give 140 mg (82%) 1-ethynyl-3-methanesulfonyl-benzene.
後処理
- customAfter usual workup, the residue was purified by column chromatography
- washeluted with hexanes/ethyl acetate (v/v=5:1
出典と根拠
- ORDレコード
- ord-bd990dca26ba4c91ac063352fb1d08d4
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08946259B2
反応ノート
読み込み中…