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Isoquinoline-3-carboxylic acid → HCID 178497277、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isoquinoline-3-carboxylic acid | HCID 124656 | — |
| 反応物 | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| 反応物 | 2-amino-6-pyridin-4-yl-1H-benzoimidazole-4-carboxylic acid methyl ester | HCID 66940503 | — |
| 生成物 | HCID 178497277 | HCID 178497277 | 75% |
反応手順
0.3 g (75%) of 2-[(isoquinoline-3-carbonyl)-amino]-6-pyridin-4-yl-3H-benzoimidazole-4-carboxylic acid methyl ester was synthesized from 0.16 g (0.09 mmol) of isoquinoline-3-carboxylic acid, 0.4 g (1 mmol) of HBTU, and 0.25 g (0.09 mmol) of the above synthesized 2-amino-6-pyridin-4-yl-1H-benzoimidazole-4-carboxylic acid methyl ester as described in general procedure A. LCMS: 424 (M+1)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08946259B2 |
| 出典データセット | uspto-grants-2015_02 |
| ORD ID | ord-0cc165cf51c44e52bb2f8a231d95d146 |
| 出典メモ | uspto-grants-2015_02 |