Water → Methyl 3-amino-5-fluoro-2-nitrobenzoate

HRID 1845057ノート

反応式

HRID 1845057 の反応式
[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[C:6](F)[C:5]=1[N+:12]([O-:14])=[O:13].C(=O)([O-])[O-].[NH4+:20].[NH4+].O>CN(C=O)C>[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[C:6]([NH2:20])[C:5]=1[N+:12]([O-:14])=[O:13]

参加物

5

反応物 3

HCID 962WaterHCID 517111Ammonium CarbonateHCID 46311132Methyl 3,5-difluoro-2-nitrobenzoate

生成物 1

HCID 58724451Methyl 3-amino-5-fluoro-2-nitrobenzoate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

6.0 g (27.5 mmol) of 3,5-difluoro-2-nitro-benzoic acid methyl ester was dissolved in DMF and treated with 2.9 g (30.25 mmol) of ammonium carbonate. The reaction was heated at 60° C. for 6 h. Water was added to the reaction mixture. The solid produced was collected by filtration and washed with water to produce 3-amino-5-fluoro-2-nitro-benzoic acid methyl ester. LCMS: 215 (M+1)+.

後処理

  1. customThe solid produced
  2. filtrationwas collected by filtration
  3. washwashed with water

出典と根拠

ORDレコード
ord-a23576bc6b43425591588abee7ce8144
出典データセット
uspto-grants-2015_02
特許番号
US08946259B2

反応ノート

読み込み中…