Hydrochloric Acid → Benzo[b]thiophene-6-carbonitrile

HRID 1845126ノート

反応式

HRID 1845126 の反応式
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[CH:10]=[C:9](C(O)=O)[S:8][C:7]=2[CH:14]=1)#[N:2].N12CCCN=C1CCCCC2.Cl>CN(C)C(=O)C>[S:8]1[CH:9]=[CH:10][C:6]2[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:14][C:7]1=2

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 106796506-Cyanobenzo[b]thiophene-2-carboxylic acid

生成物 1

HCID 21816574Benzo[b]thiophene-6-carbonitrile

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

実験手順

A microwave vial was charged with 6-cyanobenzo[b]thiophene-2-carboxylic acid (1.90 g, 9.35 mmol), 1,8-diazabicyclo[5.4.0]undec-7-ene (5.6 mL, 37.4 mmol) and N,N-dimethylacetamide (15 mL) and the reaction was subjected to microwave irradiation at 190° C. for 1 hour. After cooling, the reaction mixture was poured into 1N aq. HCl and extracted with ethyl acetate. The organic phase was concentrated under reduced pressure to get the product as light brown solid.

後処理

  1. customirradiation at 190° C. for 1 hour
  2. temperatureAfter cooling
  3. extractionextracted with ethyl acetate
  4. concentrationThe organic phase was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-524232558f104bde85cd2a4ee03859a5
出典データセット
uspto-grants-2015_02
特許番号
US08946439B2

反応ノート

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