Ethyl 5-(hydroxymethyl)-4'-methylbiphenyl-3-carboxylate → Ethyl 5-formyl-4'-methylbiphenyl-3-carboxylate

HRID 1845257ノート

反応式

HRID 1845257 の反応式
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:6]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=2)[CH:8]=1>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[CH:2]([C:3]1[CH:4]=[C:5]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:6]=[C:7]([C:9]2[CH:10]=[CH:11][C:12]([CH3:15])=[CH:13][CH:14]=2)[CH:8]=1)=[O:1]

参加物

4

反応物 1

HCID 58188190Ethyl 5-(hydroxymethyl)-4'-methylbiphenyl-3-carboxylate

生成物 1

HCID 58188063Ethyl 5-formyl-4'-methylbiphenyl-3-carboxylate

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of ethyl 5-(hydroxymethyl)-4′-methylbiphenyl-3-carboxylate (400 mg, 1.5 mmol) and manganese(IV) oxide (660 mg, 6.6 mmol) in methylene chloride (14 mL) was stirred at room temperature overnight. The reaction mixture was filtered through Celite and washed with methylene chloride. The filtrate was concentrated to afford the title compound.

後処理

  1. filtrationThe reaction mixture was filtered through Celite
  2. washwashed with methylene chloride
  3. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-e35decb50e3d4e4d9d5307a8910fa373
出典データセット
uspto-grants-2015_02
特許番号
US08946439B2

反応ノート

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