化工社化工社 化学情報印刷レポート · 研究参考用
Dibutyltin oxide → 2-Hydroxy-4-octyloxy-benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dibutyltin oxide | HCID 61221 | — |
| 反応物 | 2-Hydroxy-4-octyloxy-benzamide | HCID 10445570 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-Hydroxy-4-octyloxy-benzonitrile | HCID 10106026 | 14.4% |
反応手順
A solution of 2-hydroxy-4-octyloxy-benzamide (5.21 g; 19.7 mmol) and dibutyltinoxide (3.65 g; 14.6 mmol) was refluxed in toluene (60 mL) for 12 days. The reaction mixture was evaporated to dryness on SiO2 and purified by column chromatography (SiO2; EtOAc/PE80-100° C.=1:4) to yield 700 mg (14%) product as yellow crystals. Mp. 69-71° C. MS (Direct; Cl): 248 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07741352B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-6c54fae39cb14701a9a8fe9b4c28e164 |
| 出典メモ | uspto-grants-2010_06 |