化工社化工社 化学情報印刷レポート · 研究参考用
Water → 2-Hydroxy-4-nitrobenzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2-Methoxy-4-nitrobenzonitrile | HCID 291867 | — |
| 反応物 | Pyridinium chloride | HCID 10176127 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 2-Hydroxy-4-nitrobenzonitrile | HCID 286148 | 95.2% |
反応手順
Pyridine hydrochloride (100 g; 0.87 mol) and 2-methoxy-4-nitro-benzonitrile (17 g; ca 96 mmol) was heated to 200° C. for 2 hours, cooled to room temperature and carefully added H2O and EtOAc. The slurry was stirred until all solid dissolved. The organic layer was isolated, washed twice with H2O, brine then dried, filtered and evaporated to dryness to yield 15 g (95%) pure product
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07741352B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-572a2f4a537f4d7ba786d836abdcf52a |
| 出典メモ | uspto-grants-2010_06 |