Water → 2-Hydroxy-4-nitrobenzonitrile

HRID 18458

反応式

HRID 18458 の反応式
Cl.N1C=CC=CC=1.C[O:9][C:10]1[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[CH:15]=[CH:14][C:11]=1[C:12]#[N:13].O>CCOC(C)=O>[OH:9][C:10]1[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[CH:15]=[CH:14][C:11]=1[C:12]#[N:13]

参加物

5

反応物 3

HCID 962WaterHCID 2918672-Methoxy-4-nitrobenzonitrileHCID 10176127Pyridinium chloride

生成物 1

HCID 2861482-Hydroxy-4-nitrobenzonitrile収率 95.2%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Pyridine hydrochloride (100 g; 0.87 mol) and 2-methoxy-4-nitro-benzonitrile (17 g; ca 96 mmol) was heated to 200° C. for 2 hours, cooled to room temperature and carefully added H2O and EtOAc. The slurry was stirred until all solid dissolved. The organic layer was isolated, washed twice with H2O, brine then dried, filtered and evaporated to dryness to yield 15 g (95%) pure product

後処理

  1. dissolutiondissolved
  2. customThe organic layer was isolated
  3. washwashed twice with H2O, brine
  4. customthen dried
  5. filtrationfiltered
  6. customevaporated to dryness

出典と根拠

ORDレコード
ord-572a2f4a537f4d7ba786d836abdcf52a
出典データセット
uspto-grants-2010_06
特許番号
US07741352B2

関連ノート

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