1-(4-Amino-6-(methylthio)-1,3,5-triazin-2-yl)ethanol → 1-(4-Amino-1,3,5-triazin-2-yl)ethanol

HRID 1845869ノート

反応式

HRID 1845869 の反応式
[NH2:1][C:2]1[N:7]=[C:6](SC)[N:5]=[C:4]([CH:10]([OH:12])[CH3:11])[N:3]=1>C(O)C.[Ni].O>[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([CH:10]([OH:12])[CH3:11])[N:3]=1

参加物

5

反応物 1

HCID 672579331-(4-Amino-6-(methylthio)-1,3,5-triazin-2-yl)ethanol

生成物 1

HCID 672560701-(4-Amino-1,3,5-triazin-2-yl)ethanol収率 76.8%

試薬・触媒・溶媒 3

HCID 935Nickel触媒HCID 702Ethanol溶媒HCID 962Water溶媒

反応条件

温度
85 °C

実験手順

To a solution of 1-(4-amino-6-(methylthio)-1,3,5-triazin-2-yl)ethanol (398 mg) in ethanol (20 mL) was added Raney nickel 50% slurry in water (6 mL) and the reaction mixture was heated to 85° C. for 30 minutes then cooled to room temperature, filtered and evaporated to give the title compound (230 mg).

後処理

  1. temperaturethen cooled to room temperature
  2. filtrationfiltered
  3. customevaporated

出典と根拠

ORDレコード
ord-4e8caa51a2e446d591c607c667a83b3b
出典データセット
uspto-grants-2015_02
特許番号
US08952001B2

反応ノート

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