Hydrochloric Acid → 5-Chlorothiazolo[5,4-b]pyridin-2(1H)-one
反応式
[Cl:1][C:2]1[N:7]=[C:6]2[S:8][C:9]([O:11]C)=[N:10][C:5]2=[CH:4][CH:3]=1.O1CCOCC1.Cl>O>[Cl:1][C:2]1[N:7]=[C:6]2[S:8][C:9](=[O:11])[NH:10][C:5]2=[CH:4][CH:3]=1参加物
5
反応条件
- 温度
- 95 °C
実験手順
To round bottom flask was added give 5-chloro-2-methoxy[1,3]thiazolo[5,4-b]pyridine (1-3) (5.76 g, 28.7 mmol), 1,4-dioxane (90 mL), and a 6N solution of HCl in water (23.9 mL, 144 mmol). The reaction mixture was then heated to 95° C. while stirring in a hot oil bath with a water cooled reflux condenser attached under an atmosphere of nitrogen for 20 minutes. The crude reaction mixture was then allowed to cool to room temperature, diluted methanol and concentrated to give 5-chloro[1,3]thiazolo[5,4-b]pyridin-2(1H)-one (1-4) as a tan solid. HRMS (M+H)+: observed=186.9731, calculated=186.9727.
後処理
- additionTo round bottom flask was added
- temperaturecooled
- temperaturereflux condenser
- customThe crude reaction mixture
- temperatureto cool to room temperature
- concentrationdiluted methanol and concentrated
出典と根拠
- ORDレコード
- ord-447eba502ec9487a979bd8372ba91c6e
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08952005B2
反応ノート
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