反応式
Cl[S:2]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[N:10][CH:9]=[CH:8]2)(=[O:4])=[O:3].Cl.Cl.N[C@@H]1CCN(S(C2C=C3C(=CC=2)C=NC=C3)(=O)=O)C1.[C:36]([O:40][C:41]([NH:43][C@H:44]1[CH2:48][CH2:47][NH:46][CH2:45]1)=[O:42])([CH3:39])([CH3:38])[CH3:37].C(N(CC)CC)C>ClCCl>[C:36]([O:40][C:41]([NH:43][C@H:44]1[CH2:48][CH2:47][N:46]([S:2]([C:5]2[CH:6]=[C:7]3[C:12](=[CH:13][CH:14]=2)[CH:11]=[N:10][CH:9]=[CH:8]3)(=[O:4])=[O:3])[CH2:45]1)=[O:42])([CH3:39])([CH3:37])[CH3:38]参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
実験手順
A dichloromethane solution (100 mL) of 6-chlorosulfonylisoquinoline (Reference Compound 2) was added with stirring at room temperature to a solution containing 423 mg of (S)-(−)-3-(tert-butoxycarbonylamino)pyrrolidine dissolved in 20 mL of dichloromethane further supplemented with 0.5 mL of triethylamine, and reacted for 6 hour. The reaction solution was washed with saturated saline and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated, and the obtained crude product was purified by silica gel column chromatography (acetone:hexane=1:2) to obtain 560 mg of the compound of interest as a colorless oil (65%).
後処理
- customreacted for 6 hour
- washThe reaction solution was washed with saturated saline
- dry with materialdried over anhydrous sodium sulfate
- filtrationAfter filtration
- concentrationthe filtrate was concentrated
- customthe obtained crude product
- customwas purified by silica gel column chromatography (acetone:hexane=1:2)
出典と根拠
- ORDレコード
- ord-de958c0ddf41474598828c5ca6db4c47
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08951997B2
関連ノート
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