Cyclopentylamine → 5-Chloro-N3-cyclopentylpyridazine-3,4-diamine

HRID 1846005ノート

反応式

HRID 1846005 の反応式
Cl[C:2]1[N:3]=[N:4][CH:5]=[C:6]([Cl:9])[C:7]=1[NH2:8].[CH:10]1([NH2:15])[CH2:14][CH2:13][CH2:12][CH2:11]1>O>[Cl:9][C:6]1[C:7]([NH2:8])=[C:2]([NH:15][CH:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)[N:3]=[N:4][CH:5]=1

参加物

4

反応物 2

HCID 2906CyclopentylamineHCID 64032013,5-Dichloro-1,4-dihydropyridazin-4-imine

生成物 1

HCID 867232335-Chloro-N3-cyclopentylpyridazine-3,4-diamine収率 90%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
150 °C

実験手順

3,5-Dichloropyridazin-4-amine (Preparation 4, 1 g, 6.09 mmol) was added to cyclopentylamine (3.0 mL, 30.41 mmol) and water (1 mL) in a stainless steel sealed container. The mixture was heated for 16 hours at 150° C. The reaction mixture was cooled to room temperature then evaporated in vacuo. The residue was purified by silica gel column chromatography eluting with EtOAc to afford the title compound as yellow solid in 90% yield, 1.17 g.

後処理

  1. temperatureThe reaction mixture was cooled to room temperature
  2. customthen evaporated in vacuo
  3. customThe residue was purified by silica gel column chromatography
  4. washeluting with EtOAc

出典と根拠

ORDレコード
ord-1f4dc9d1574540559185f6c4003763ef
出典データセット
uspto-grants-2015_02
特許番号
US08952008B2

反応ノート

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