Hydroxylamine → Ethyl 6-chloro-2-fluoro-3-((hydroxyimino)methyl)benzoate

HRID 1846107ノート

反応式

HRID 1846107 の反応式
[CH2:1]([O:3][C:4](=[O:15])[C:5]1[C:10]([Cl:11])=[CH:9][CH:8]=[C:7]([CH:12]=O)[C:6]=1[F:14])[CH3:2].[NH2:16][OH:17]>CO>[CH2:1]([O:3][C:4](=[O:15])[C:5]1[C:10]([Cl:11])=[CH:9][CH:8]=[C:7]([CH:12]=[N:16][OH:17])[C:6]=1[F:14])[CH3:2]

参加物

4

反応物 2

HCID 787HydroxylamineHCID 58483266Ethyl 6-chloro-2-fluoro-3-formylbenzoate

生成物 1

HCID 76800184Ethyl 6-chloro-2-fluoro-3-((hydroxyimino)methyl)benzoate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
55 °C

実験手順

A mixture of 6-chloro-2-fluoro-3-formyl-benzoic acid ethyl ester (4.04 g; 17.52 mmol), hydroxylamine (50% aq. solution, 4.29 mL; 70 mmol) in MeOH (60 mL) was stirred at 55° C. for 1.5 h. The mixture was concentrated i. vac., diluted with EtOAc, washed with brine, dried over Na2SO4 and concentrated i.vac. to furnish the subtitle compound.

後処理

  1. concentrationThe mixture was concentrated i
  2. addition, diluted with EtOAc
  3. washwashed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated i.vac

出典と根拠

ORDレコード
ord-dd0871d3f04b4e3790673be115def190
出典データセット
uspto-grants-2015_02
特許番号
US08951999B2

反応ノート

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