Benzaldehyde, 2-hydroxy-5-methyl- → 2-[[1-(4-Chloro-benzyl)-1H-tetrazol-5-yl]-(3-imidazol-1-yl-propylamino)-methyl]-4-methyl-phenol

HRID 18462

反応式

HRID 18462 の反応式
[N:1]1([CH2:6][CH2:7][CH2:8][NH2:9])[CH:5]=[CH:4][N:3]=[CH:2]1.[OH:10][C:11]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][C:12]=1[CH:13]=O.C[Si]([N:24]=[N+:25]=[N-:26])(C)C.[Cl:27][C:28]1[CH:33]=[CH:32][C:31]([CH2:34][N+:35]#[C-:36])=[CH:30][CH:29]=1>CO>[Cl:27][C:28]1[CH:33]=[CH:32][C:31]([CH2:34][N:35]2[C:36]([CH:13]([NH:9][CH2:8][CH2:7][CH2:6][N:1]3[CH:5]=[CH:4][N:3]=[CH:2]3)[C:12]3[CH:15]=[C:16]([CH3:19])[CH:17]=[CH:18][C:11]=3[OH:10])=[N:26][N:25]=[N:24]2)=[CH:30][CH:29]=1

参加物

6

反応物 4

HCID 69184Benzaldehyde, 2-hydroxy-5-methyl-HCID 78378AzidotrimethylsilaneHCID 787361H-Imidazole-1-propanamineHCID 27574091-Chloro-4-(isocyanomethyl)benzene

生成物 1

HCID 250622412-[[1-(4-Chloro-benzyl)-1H-tetrazol-5-yl]-(3-imidazol-1-yl-propylamino)-methyl]-4-methyl-phenol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3-Imidazol-1-yl-propylamine (1 mmol) and 2-Hydroxy-5-methyl-benzaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours Trimethylsilylazide (5 mmol) and 1-Chloro-4-isocyanomethyl-benzene (1 mmol) was added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.

後処理

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

出典と根拠

ORDレコード
ord-9eb22706214142e0979a67926478b28b
出典データセット
uspto-grants-2010_06
特許番号
US07741354B2

関連ノート

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