Hydrochloric Acid → HCID 54710388、化合物
反応式
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][N:10]=2)[N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.CC1OCCC1.Cl.O1CCOCC1>CCOC(C)=O>[NH:5]1[C:6]2[C:11](=[N:10][CH:9]=[CH:8][CH:7]=2)[C:2](=[O:1])[CH2:3][CH2:4]1参加物
6
実験手順
To a solution of tert-butyl 4-oxo-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate (1 eq.) and 2-MeTHF (0.2 M) is added 4M HCl in dioxane (5 eq.). The reaction is monitored by TLC. The reaction is diluted with EtOAc and washed with saturated NaHCO3. The organic solution is dried over MgSO4 and concentrated in vacuo. The compound that may be thus obtained is purified by column chromatography to give the title compound.
後処理
- washwashed with saturated NaHCO3
- dry with materialThe organic solution is dried over MgSO4
- concentrationconcentrated in vacuo
- customThe compound that may be thus obtained
- customis purified by column chromatography
出典と根拠
- ORDレコード
- ord-b987a6e58c364847b5da333618fcc3a9
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08952009B2
反応ノート
読み込み中…